NETWORK-BASED CLUSTERING UNVEILS INTERCONNECTED LANDSCAPES OF GENOMIC AND CLINICAL FEATURES ACROSS MYELOID MALIGNANCIES

Network-based clustering unveils interconnected landscapes of genomic and clinical features across myeloid malignancies

Eyebrow Enhancers Abstract Myeloid malignancies exhibit considerable heterogeneity with overlapping clinical and genetic features among subtypes.We present a data-driven approach that integrates mutational features and clinical covariates at diagnosis within networks of their probabilistic relationships, enabling the discovery of patient subgroups.

read more

Identification of novel variants of metadherin in breast cancer.

Metadherin (MTDH, also known as AEG-1, and Lyric) has been demonstrated to play a potential role Eyebrow Enhancers in several significant aspects of tumor progression.It has been reported that overexpression of MTDH is associated with progression of disease and poorer prognosis in breast cancer.However, there are no studies to date assessing varian

read more

Comprehensive Second-Order Adjoint Sensitivity Analysis Methodology (2nd-ASAM) Applied to a Subcritical Experimental Reactor Physics Benchmark: I. Effects of Imprecisely Known Microscopic Total and Capture Cross Sections

The subcritical polyethylene-reflected plutonium (PERP) metal fundamental physics benchmark, which is included in the Nuclear Energy Agency (NEA) International Criticality Safety Benchmark Evaluation Project (ICSBEP) Handbook, has been selected to serve as a paradigm illustrative reactor physics system for the application of the Second-Order Adjoin

read more

A Comprehensive Exploration of Unsupervised Classification in Spike Sorting: A Case Study on Macaque Monkey and Human Pancreatic Signals

Spike sorting, an indispensable process in the analysis of neural biosignals, aims to segregate individual action potentials from mixed recordings.This study delves into a comprehensive investigation of diverse unsupervised classification algorithms, some of which, to the best of our knowledge, have not previously been used for spike sorting.The me

read more